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Symbol
Name
ID

Syn1
synapsin I
MGI:98460

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Autistic behavior	Aggressive behavior	Intellectual disability, mild	Specific learning disability	Seizure	Focal-onset seizure
Disease(s) Associated with SYN1	Autistic behavior	Aggressive behavior	Intellectual disability, mild	Specific learning disability	Seizure	Focal-onset seizure
non-syndromic X-linked intellectual disability 50
X-linked epilepsy with variable learning disabilities and behavior disorders

Mouse Phenotypes

abnormal seizure response to electrical stimulation

convulsive seizures

abnormal hippocampus pyramidal cell morphology

abnormal CNS synapse formation

delayed CNS synapse formation

abnormal synaptic vesicle clustering

abnormal synaptic vesicle recycling

abnormal excitatory postsynaptic potential

abnormal inhibitory postsynaptic currents

increased synaptic depression

abnormal neurotransmitter secretion

enhanced paired-pulse facilitation

Availability

Mouse Genotype

Syn1^tm1Noh/Syn1^tm1Noh

Syn1^tm1Pggd/Syn1^tm1Pggd

Syn1^tm1Sud/Syn1^tm1Sud

Syn1^tm2Noh/Syn1^tm2Noh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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